At the moment, the genome sequences of 23 A. In 2007, the genome sequence of the enzyme-producing strain CBS 513.88 was published, followed by the sequencing of the citric acid-producing strain ATCC 1015 in 2011. įirst genome sequencing projects were focused on industrial relevant strains. The United States Food and Drug Administration has given it GRAS (Generally Regarded As Safe) status because of its long history of industrial use. Since the early twentieth century it has become a major industrial producer of organic acids, such as citric and gluconic acid, and enzymes, including amylases and phytases. Its versatile metabolism allows it to grow in a wide variety of environments. niger and could contribute to the investigation and potential discovery of sexuality in this species long thought to be asexual.Īspergillus niger is a filamentous fungus classified in the section Nigri of the genus Aspergillus. These results provide new insights in the mating system of A. niger strain, suggests the occurrence of genetic flipping or switching events at the MAT1–1 locus of A. This study, besides providing a high-quality genome sequence of an important A. In contrast, the region comprising the MAT1–1 locus is flipped in all sequenced strains of A. The genomic organization of the MAT1–2 locus in CBS 554.65 is similar to other Aspergillus species. niger half of them had a MAT1–1 locus and the other half a MAT1–2 locus. A nucleotide alignment showed a different orientation of the MAT1–1 locus of ATCC 1015 compared to the MAT1–2 locus of CBS 554.65, relative to conserved genes flanking the MAT locus. niger strains, such as ATCC 1015 and CBS 513.88, which contain a MAT1-1-1 gene. Bioinformatic analyses revealed the presence of a MAT1-2-1 gene in this genome, contrary to the most commonly used A. In addition, a complete circular mitochondrial DNA assembly was obtained. The assembly covered all the 8 centromeric regions of the chromosomes. A high-quality nuclear genome sequence consisting of 17 contigs with a N50 value of 4.07 Mbp was obtained. The genome of CBS 554.65 was sequenced with PacBio. These, however, do not include the neotype strain CBS 554.65. Nowadays, the genome sequences of more than 20 A. Its genome was one of the first Aspergillus genomes to be sequenced in 2007, due to its economic importance and its role as model organism to study fungal fermentation. Aspergillus niger is a ubiquitous filamentous fungus widely employed as a cell factory thanks to its abilities to produce a wide range of organic acids and enzymes.
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